منابع مشابه
Anti-HIV Activities of Intramolecular G4 and Non-G4 Oligonucleotides.
New natural and chemically modified DNA aptamers that inhibit HIV-1 activity at submicromolar concentrations (presumably via preventing viral entry into target cells) are reported. The new DNA aptamers were developed based on known intramolecular G-quadruplexes (G4s) that were functionally unrelated to HIV inhibition [the thrombin-binding aptamer and the fragment of the human oncogene promoter ...
متن کاملG4 Resolvase 1 tightly binds and unwinds unimolecular G4-DNA
It has been previously shown that the DHX36 gene product, G4R1/RHAU, tightly binds tetramolecular G4-DNA with high affinity and resolves these structures into single strands. Here, we test the ability of G4R1/RHAU to bind and unwind unimolecular G4-DNA. Gel mobility shift assays were used to measure the binding affinity of G4R1/RHAU for unimolecular G4-DNA-formed sequences from the Zic1 gene an...
متن کاملBorate minerals stabilize ribose.
Evidence for an “RNA world,” an episode of life on Earth during which RNA was the only genetically encoded component of biological catalysts, is found in the ribosome (1), catalytic RNA molecules (2), and contemporary metabolism (3). That RNA could form spontaneously and persist under prebiotic conditions has been doubted, however (4, 5). Ribose and its sister pentoses (arabinose, xylose, and l...
متن کاملPotassium zinc borate, KZnB3O6
The title compound, KZnB(3)O(6) contains a remarkable [B(6)O(12)](6-) group ( symmetry) formed by two rings linked by edge-sharing BO(4) tetra-hedra, a feature that has only been observed previously under high pressure conditions. These borate groups are connected through distorted ZnO(4) tetra-hedra in edge-shared pairs ( symmetry), forming a three-dimensional network whose cavities are filled...
متن کاملThe G4 Genome
Recent experiments provide fascinating examples of how G4 DNA and G4 RNA structures--aka quadruplexes--may contribute to normal biology and to genomic pathologies. Quadruplexes are transient and therefore difficult to identify directly in living cells, which initially caused skepticism regarding not only their biological relevance but even their existence. There is now compelling evidence for f...
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ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2015
ISSN: 0002-7863,1520-5126
DOI: 10.1021/jacs.5b02753